IMCSzyme-black.png
 

consistent, stable and pure enzymes

MADE in USA. IMCSzyme is a genetically modified pure
beta-glucuronidase. Our pure enzyme hydrolyzes multiple drug classes quickly and with high efficiency. IMCS has an extensive quality control program and manufacturing process that ensures consistency across lots. Our product is shipped overnight and stored at 2 - 8 °C. IMCSzyme is used to hydrolyze over a million samples each month.

Our product has been featured in poster presentations at AACC, MSACL, SOFT, AAFS, ASMS and published in the Journal of Analytical Toxicology.

Contact us for a free sample. 

  • Clean, fast and comprehensive hydrolysis in <30 minutes 
  • Deconjugate 100% percent of glucuronides 
  • Reduce matrix effects- less interferents 
  • Decrease preparation times and increase throughput 

 

Samples

 

 

Orders

 

  • slide
  • slide
  • slide

Tested on real patient urine containing excess glucuronides to produce accurate results.

Analyte Recovery >90% hydrolysis  Time (minutes) Target Analyte Concentration (ng/mL) Other Glucuronides >2500 glucuronides ng/mL
THCA 0 100
Amitriptyline  0 500
Benzodiazapine 5 2500
Norbuprenorphine 15 500
Morphine 3  15 500
Temazepam 0 500
Codeine-6 15 30,000

 

no-incubation.jpg
30-minute.jpg

 

Product Specification:

Physical Description:

Clear aqueous solution

Specific Activity (units*/mL):

>50,000

Guaranteed Shelf Life:

6 months 

Storage Temperature: 

2 - 8 °C

Suflatase Activity: 

None detected

* One modified Fishman unit will liberate 1 microgram of phenolphthalein from phenolphthalein glucuronide per hour at 25 °C at pH 6.8 (30 minute assay)
† Sulfatase activity measured using para-nitrocatechol sulfate with 10 µg of purified enzyme at pH 6.8, 55 °C (1 hour).


 

Rapid Hydrolysis Buffer Included in every order

The use of our complimentary Rapid Hydrolysis Buffer ensures proper pH for optimal hydrolysis conditions with IMCSzyme.



resources

HYDROLYZING 30,000 NG/ML
CODEINE-6-GLUCURONIDE 
IN 15 MINUTES 
 

Application note on optimized hydrolysis of opiates in urine
 

View Document
 

SCREENING AND QUANTIFICATION OF PAIN AND ANTIDEPRESSANT DRUGS IN URINE 

Technical note summary of an independent poster presentation from SOFT 2016 

View Document 

RAPID HYDROLYSIS OF OPIATES AND OPIOIDS IN URINE

 SOFT 2016 Poster Presentation

View Document 

HYDROLYSIS USING IMCSZYME FOR PAIN MANAGEMENT DRUG TESTING

 Technical note summary of an independent poster presentation from MSACL 2015

View Document 

EVALUATION OF β-Glucuronidase ENZYMES AND SAMPLE CLEANUP METHODS  

Technical note summary of a Journal of Analytical Toxicology article

View Document

FAST, SIMPLE, ACCURATE METHOD FOR URINE DRUGS OF ABUSE SCREENING  

Technical note summary of an independent poster presentation from SOFT 2015

View Document

 

 

Technical Documents

 

 

footer-logo.png

CAREERS PRIVACY POLICY