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IMCS

IMCS

A leader in recombinant enzymes and automated micro-chromatography technologies

  • ABOUT
    • ABOUT IMCS
    • QUALITY POLICY
    • RESEARCH AT IMCS
    • CAREERS
  • PRODUCTS
    • IMCSzyme®
      • IMCSzyme E1F
      • IMCSzyme RT
      • IMCSzyme® CATALOG
    • IMCStips®
      • APPLICATIONS
        • AFFINITY
        • SIZE EXCLUSION
        • NUCLEIC ACIDS
        • ION EXCHANGE
        • REVERSE PHASE
        • PHOSPHOPEPTIDE
      • IMCStips® CATALOG
      • AUTOMATION PLATFORMS
        • DYNAMIC DEVICES
        • HAMILTON
        • INTEGRA
        • TECAN
        • OPENTRONS
        • ANALYTIK JENA
    • SULFATASES
      • Sulfazyme
      • Sulfazyme™ DS
      • Sulfazyme™ β-AS
    • GLYCO REAGENTS
      • GLYCOLIPIDS
      • ACTIVATED SUGARS
      • BIOSYNTHETIC ENZYMES
      • SMALL MOLECULES
    • SPHINGOSINES
    • OTHER PROTEINS
      • PURIFIED STREPTAVIDIN
      • B. pi. β-glucuronidase variant
  • SERVICES
    • BETA-GLUCURONIDASES & SULFATASES
      • β-GLUCURONIDASE VALIDATION SERVICES
      • HIGH-THROUGHPUT TOXICOLOGY WORKFLOWS
    • IMCStips®
      • SAMPLE PREPARATION AUTOMATION
      • HIGH-THROUGHPUT METHOD DEVELOPMENT
      • AUTOMATION PLATFORMS
        • DYNAMIC DEVICES
        • HAMILTON
        • INTEGRA
        • TECAN
        • OPENTRONS
        • ANALYTIK JENA
    • OTHER SERVICES
      • GLYCAN PRODUCTION (Coming Soon)
      • R&D COLLABORATIONS
      • EXTRACELLULAR VESICLES
  • RESOURCES
    • FAQ
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    • SAFETY DATA SHEETS
    • CERTIFICATE OF ANALYSIS
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LATEST NEWS

Plasmid Purification using 5 mL MidiPure™ IMCStips® on the Dynamic Devices Lynx

December 11, 2024

Plasmid DNA (pDNA) purification is a vital process in molecular biology, genetic engineering, and biotechnology. Traditional mid-scale purification methods, like vacuum manifolds or centrifuge columns, can be slow and limited in throughput. MidiPure™ IMCStips® on the Dynamic Devices platform streamlines pDNA purification in high-throughput environments with...

Read morePlasmid Purification using 5 mL MidiPure™ IMCStips® on the Dynamic Devices Lynx

In-well hydrolysis at room temperature with IMCSzyme® RT and β-Gone™ Plus

October 20, 2023

Learn how you could save time with in-well hydrolysis of urine at room temperature for drug testing with the help of IMCSzyme® RT and β-Gone™ Plus β-Glucuronidase Removal Plates (Phenomenex). This in-well hydrolysis method allows you to: Save significant time by conducting hydrolysis directly in the well at room temperature, utilizing IMCSzyme® RT alongside β-Gone™ …

Read moreIn-well hydrolysis at room temperature with IMCSzyme® RT and β-Gone™ Plus

South Carolina-based IMCS, Tymora Analytical Strengthen Partnership to Streamline Exosome Research

August 9, 2023

Exosomes gaining attention in biomedical research for potential as diagnostic and therapeutic tools IRMO, S.C. – August 9, 2023 — South Carolina’s Integrated Micro-Chromatography Systems, Inc. (IMCS), a leader in automating laboratory workflows, and Tymora Analytical, an authority in exosome purification and proteomics services, have announced a significant enhancement to their ongoing collaboration to advance …

Read moreSouth Carolina-based IMCS, Tymora Analytical Strengthen Partnership to Streamline Exosome Research
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Journal Article: Incorporation of Automated Buffer Exchange Empowers High-Throughput Protein and Plasmid Purification for Downstream Uses

March 7, 2023

Our latest publication in SLAS Technology highlights IMCS’s successful incorporation of automated buffer exchange into two fully automated workflows: affinity purification and anion exchange. By using pipet-based dispersive solid-phase extraction (dSPE), these workflows are highly adaptable and can address production constraints for biotherapeutics. The inclusion of buffer exchange as a last step in both workflows enables further integration for downstream processing, saving valuable time and increasing efficiency. These findings demonstrate the benefits of incorporating IMCStips into high-throughput protein and plasmid purification, paving the way for a more streamlined and effective biotherapeutics discovery process.

Read moreJournal Article: Incorporation of Automated Buffer Exchange Empowers High-Throughput Protein and Plasmid Purification for Downstream Uses

IMCS Scientists Awarded Patent for Enzyme Engineering Technology

November 1, 2022

IRMO, S.C. (November 1, 2022) — Integrated Micro-Chromatography Systems, Inc. (IMCS), a leader in recombinant enzymes and micro-chromatography technologies, was awarded U.S. Patent No. 11,421,210 by the United States Patent Office. The patent, entitled “Chimeric and other variant beta-glucuronidase enzymes with enhanced properties,” is a new addition to their existing patents based on proprietary enzyme …

Read moreIMCS Scientists Awarded Patent for Enzyme Engineering Technology
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IMCStips® and Hamilton CO-RE® II

October 4, 2022

IMCStips® are compatible with CO-RE® II (Compression O-Ring Expansion), an upgraded pipette tip technology from Hamilton Company. This new tip handling and design standard ensures improved tip longevity, alignment, and precision. IMCStips® and the updated CO-RE II tips continue to be compatible with the original CO-RE® head from Hamilton. As part of our active collaboration …

Read moreIMCStips® and Hamilton CO-RE® II
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Customize Your Workflow

IMCS recognizes our customers’ needs vary, which is why we provide tailored tools and services to help you reach your laboratory’s goals.

VIEW OUR CUSTOM SOLUTIONS

ABOUT IMCS

INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC. (IMCS) IS A BIOTECHNOLOGY COMPANY FOCUSED ON DELIVERING TOOLS AND SERVICES THAT HELP PAVE THE WAY FOR THE FUTURE OF PRECISION MEDICINE. WE STRIVE TO ADDRESS THE GROWING NEEDS OF CLINICAL AND RESEARCH LABORATORIES THROUGH ADVANCED TECHNOLOGIES THAT INCREASE TESTING EFFICIENCY AND ACCURACY.

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ABOUT

ABOUT IMCS

CAREERS

QUALITY POLICY

RESEARCH AT IMCS

PRODUCTS

IMCSZYME

IMCSZYME RT

IMCSTIPS

PROTEINS, ENZYMES, RESINS

GLYCO REAGENTS

TERMS

TERMS OF USE

PRIVACY POLICY

STANDARD TERMS AND CONDITIONS

FCOI POLICY

CONNECT WITH US

IMCS, Inc. Headquarters
110 Centrum Drive
Irmo, SC 29063

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COPYRIGHT © 2026 · IMCS · ALL RIGHTS RESERVED ·

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Caleb R. Schlachter, Ph.D.

Principal Scientist
Caleb R. Schlachter, Ph.D., as the Principal Scientist at IMCS, leads and provides guidance for several research and development projects that involve proteins, including enzymes for glycan hydrolysis and glycan synthesis. He has co-authored multiple patents, posters, and peer-reviewed articles on β-glucuronidases and sulfatases.
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Gray D. Amick, Ph.D.

Director of Operations
Gray D. Amick, Ph.D., is the Director of Operations at IMCS with over 26 years of experience in forensic DNA analysis and toxicology. Prior to joining IMCS, he led forensic DNA testing for the Richland County Sheriff’s Department as technical leader and lab director. He has been court-qualified as an expert over 100 times and has authored and co-authored multiple posters and peer-reviewed articles.
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Amanda C. McGee

Research Scientist
Amanda C. McGee is a Research Scientist at IMCS involved with enzyme characterizations, new analytical method developments, and advanced technical support. She joined IMCS with several years of experience in analytical testing for active pharmaceutical ingredients as per cGMP, USP and ICH guidelines. She has co-authored peer reviewed articles in the Journal of Analytical Toxicology and presented research at national and international conferences.
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L. Andrew Lee, Ph.D.

Co-Founder and Chief Scientific Officer
L. Andrew Lee, Ph.D. co-founded IMCS and leads research and development efforts in enzyme engineering and automated micro-chromatography workflows. He directs new market efforts in glycan synthesis, supported by three NIH Fast-Track awards.

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