Flexible Sample Processing to Alleviate Workflow Challenges
IMCStips technology uses dispersive solid-phase extraction (dSPE) to provide simplified, highly efficient micro-purifications. The loose resin contained within IMCStips improves workflow efficiencies by facilitating the enhanced binding of analytes of interest during pipetting steps. By coupling this technology with the Hamilton automated liquid handling platform, methods are streamlined with the hands-free implementation of multiple aspirate and dispense cycles that facilitate consistent results, high recoveries, and faster workflows.
BENEFITS
- Processes up to 96 samples in under 30 minutes
- Selectable parameters easily configured by the user include different mixing cycles,
various volumes, and other optional steps - Combines integrated purification with Hamilton’s robust technology to create fully
automated methods for handling time intensive manual procedures
RESINS & APPLICATIONS
| AFFINITY | SIZE EXCLUSION | NUCLEIC ACIDS |
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| ION EXCHANGE | PHOSPHOPEPTIDE | REVERSE PHASE |
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| Resin Options | Resin Options | Resin Options |
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| Applications | Applications | Applications |
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Analyte binding per aspiration was assessed using bromophenol blue dye diluted in water at varying concentrations. The binding capacity of IMCStips is limited by concentration as well as the chemical property of the analyte of interest (i.e logP values).
Purification of a single log of CHO cell fermentation using MabSelect SuRe LX resin (50 μL resin bed) by centrifugation (spin) and IMCStips. For consistency, the spin method utilized 100 x g RCF for five minutes and flow through samples were re-applied to the column either 3x or 5x, similar to the tip format. Spin format consistency yielded less mAb than tip based format, as indicated by the UV-Vis measurements (Abs @ 280 nm) above.
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"Working with the IMCS team has been great! I appreciate the flexibility IMCS has to allow us to send in resins and have custom tips made. This allows us to be innovative in our processes, which is always a good thing!"
"Super customer service and support. Want to sincerely help out and not only sell their product! Very knowledgeable automation team. Overall, one of best companies to work with."
"I've been very pleased with IMCS. The buffer and enzyme have performed well for our laboratory. The customer service has been excellent as well!"
"I love your customer service! Especially how quickly they get the enzyme out to us, it has been a Godsend! keep up the excellent work!"
"Great company and very helpful when needed."
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"I am very pleased with the quality of IMCS products and have always received great customer service from the IMCS team."
"Overall, very happy. Especially impressed that we did not have any supply issues during the pandemic!!! Thank you!!"
"Nothing better on the market in terms of quality and final product's purity and yield."
“We are observing some of the best purification we've ever seen. Kudos to you both for helping me get things back in order!”
"The sales and method development team [are] friendly and highly responsive."
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