Affordable Enzymes and Kits for Glycobiology Research
We provide the expertise and the building blocks so you can keep building and discovering
One-Pot MultiEnzyme (OPME) approaches represent a highly efficient and cost-effective strategy, offering both high yields and the potential for multi-kilo ton scale-up. Furthermore, the OPME method facilitates cleaner reactions with reduced byproducts, streamlining the purification process.
The OPME method involves a chemoenzymatic synthesis approach, eliminating intermediate steps and significantly increasing synthesis efficiency. In this process, enzymes required for the biosynthesis of nucleotide donors can be seamlessly combined with glycosyltransferases in a "one pot" reaction, maintaining high purity and yields.
Leveraging the OPME technology, we are delighted to offer affordable glycosyltransferases, nucleotidyltransferases, activated sugars, and glycan synthesis kits. These products aim to expedite research in the field of glycobiology by overcoming traditional limitations, such as the high cost of reagents and materials, and the reliance on animal sources for certain compounds like gangliosides.
Enzymatic Synthesis of Gangliosides
represents the molecule number in the SphingoMap
Supported by funding from the National Institute of General Medical Sciences of the National Institutes of Health, IMCS utilizes its expertise in recombinant enzyme engineering and manufacturing to empower the scientific community. Our goal is to provide researchers with accessible, high-quality tools and materials, revolutionizing glycobiology without straining budgets.
With a focus on affordability, ease of use, and promoting advancements in glycobiology, our reaction kits are designed to facilitate the synthesis of various glycans, contributing to groundbreaking scientific discoveries. Join us in our mission to democratize glycobiology and drive transformative progress in this critical scientific field.
"If you give us the pieces to build the Lego [structure], we can generate the tools to study anything from cell activity to testing potential therapeutics. You can use this to build anything. You can build a mimetic library."
-- Ronald Schnaar, Ph.D., Professor of Pharmacology
Johns Hopkins University School of Medicine
"Some experiments with glycolipids are cost-prohibitive, but scalable and facile access to glycolipids would make such experiments financially feasible... a tremendous help for a lab that doesn’t have expertise with glycan synthesis and doesn’t want to invest in getting all these enzymes expressed."
-- Matthew Macauley, Ph.D., Assistant Professor of Chemistry
University of Alberta
Available Products
Glycolipids
Activated Nucleotidyl Sugars
Biosynthetic Enzymes
Small Molecules
Resources
- ACS 2023: Stabilization of Bacterial Glycoenzymes Involved in One-Pot MultiEnzyme Reactions
- ACS 2023: One-Pot MultiEnzyme (OPME) Sialylation Kits for Custom Ganglioside Synthesis
- ACS 2023: Commercial Production of Recombinant Sialic Acid Aldolase for One-Pot Multi-Enzyme (OPME) Synthesis of Neu5Gc-Containing Sialosides
