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IMCS

IMCS

A leader in recombinant enzymes and automated micro-chromatography technologies

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ON-DEMAND WEBINAR:

Balancing Column Deterioration with Enzyme Performance for Drug of Abuse Hydrolysis

Presenter: Amanda C. McGee Expand

Amanda McGee is a Research Scientist at IMCS with over 10 years of experience in the manufacturing, pharmaceutical, and biotech industries. She earned her bachelor's degree in chemistry with a concentration in forensic science from Newberry College in 2012. Her career began shortly after graduation, working at IRIX Manufacturing as an Active Pharmaceutical Ingredient Stability Scientist for three years, followed by three years at Nephron Pharmaceuticals as a Quality Control Analyst.

In 2018, Amanda joined IMCS as a Research Associate, where she has since grown into her current role as Research Scientist. Her work involves protein characterization, quality control method transfers, and customer technical support. She has made significant technical contributions to the company's next-generation enzyme work, as evidenced by her co-authorship of two publications: "Variants of Glycosyl Hydrolase Family 2 B-Glucuronidases have Increased Activity on Recalcitrant Substrates" and "Factors Compromising Glucuronidase Performance in Urine Drug Testing Potentially Resulting in False Negatives." At IMCS, Amanda is focused on applying her expertise to improve the quality and efficiency of next-generation enzymes.

Are you striving to improve the cost-efficiency and accuracy of your lab's drug abuse testing? Wondering how enzyme performance could directly affect column life and test reliability? Curious about what sets a high-quality β-glucuronidase like IMCSzyme RT apart? Then, this on-demand webinar is a must-watch.

Join speaker Amanda McGee as she provides a comprehensive overview of the vital balance between enzyme performance and column deterioration. Amanda presents a detailed study exploring the effects of various amounts of β-glucuronidase protein on drug analyte recoveries and column longevity. This study challenges enzyme performance in patient samples using a range of enzyme amounts in pooled, problematic urine samples. Using too little enzyme will result in low analyte recoveries and potential false negatives, while using too much enzyme without the proper sample preparation will result in column deterioration and poor peak shape quality.

By investing your time in this webinar, you'll gain valuable insights into how the optimal enzyme concentration not only guarantees high-quality peak shapes and accurate test results but also helps prevent expensive reruns, column replacements, and machine downtime. Discover why choosing high-quality enzymes like IMCSzyme RT is a strategic investment that delivers superior performance and significant cost savings. Access this essential resource at your leisure and share it with your colleagues to take your lab's drugs of abuse testing to the next level.

At the end of this eye-opening webinar, you will:

  • Understand the effects of different concentrations of β-glucuronidases on glucuronidated compounds' hydrolysis and the subsequent impact on analyte detection.
  • Learn about the relationship between enzyme usage and LC column life, focusing on how to avoid deterioration and poor peak shape quality.
  • Gain insights into strategies to balance enzyme performance with the need for accurate and reliable drug testing results, minimizing potential false negatives.
View Webinar

ACCESS OUR ON-DEMAND WEBINAR TODAY!

Balancing Column Deterioration with Enzyme Performance for Drug of Abuse Hydrolysis

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ABOUT IMCS

INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC. (IMCS) IS A BIOTECHNOLOGY COMPANY FOCUSED ON DELIVERING TOOLS AND SERVICES THAT HELP PAVE THE WAY FOR THE FUTURE OF PRECISION MEDICINE. WE STRIVE TO ADDRESS THE GROWING NEEDS OF CLINICAL AND RESEARCH LABORATORIES THROUGH ADVANCED TECHNOLOGIES THAT INCREASE TESTING EFFICIENCY AND ACCURACY.

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Caleb-Schlachter-for-web

Caleb R. Schlachter, Ph.D.

Principal Scientist
Caleb R. Schlachter, Ph.D., as the Principal Scientist at IMCS, leads and provides guidance for several research and development projects that involve proteins, including enzymes for glycan hydrolysis and glycan synthesis. He has co-authored multiple patents, posters, and peer-reviewed articles on β-glucuronidases and sulfatases.
Gray Amick for web

Gray D. Amick, Ph.D.

Director of Operations
Gray D. Amick, Ph.D., is the Director of Operations at IMCS with over 26 years of experience in forensic DNA analysis and toxicology. Prior to joining IMCS, he led forensic DNA testing for the Richland County Sheriff’s Department as technical leader and lab director. He has been court-qualified as an expert over 100 times and has authored and co-authored multiple posters and peer-reviewed articles.
Amanda M Headshot

Amanda C. McGee

Research Scientist
Amanda C. McGee is a Research Scientist at IMCS involved with enzyme characterizations, new analytical method developments, and advanced technical support. She joined IMCS with several years of experience in analytical testing for active pharmaceutical ingredients as per cGMP, USP and ICH guidelines. She has co-authored peer reviewed articles in the Journal of Analytical Toxicology and presented research at national and international conferences.
Andrew_Headshot

L. Andrew Lee, Ph.D.

Co-Founder and Chief Scientific Officer
L. Andrew Lee, Ph.D. co-founded IMCS and leads research and development efforts in enzyme engineering and automated micro-chromatography workflows. He directs new market efforts in glycan synthesis, supported by three NIH Fast-Track awards.

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