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IMCS

IMCS

A leader in recombinant enzymes and automated micro-chromatography technologies

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WEBINARS

SOFT 2020 ON-DEMAND SHOWCASE SESSION:

How Enzymes Fail: The Hidden Secrets of Urine-Induced Inhibition

Presenter: Ana Grenier, Ph.D. Expand

Dr. Ana Grenier has more than 20 years of analytical experience in analytical method development in a variety of industries including the food, pharmaceutical and clinical industries. She received her PhD from the University of Guadalajara (Mexico) where her research focused on developing analytical techniques for monitoring aging makers in Tequila. Since then she has worked in a variety of positions within the pharmaceutical industry in the greater Boston area. In her current position, Dr. Ana Grenier is a Research Scientist in the analytical development group at Dominion Diagnostics where she focuses primarily on utilizing high resolution accurate mass spectrometry for measuring drug levels in human biological fluids.

Presenter: Nikki Sitasuwan, Ph.D. Expand

Dr. Sitasuwan received her Ph.D. in Chemistry and Biochemistry from the University of South Carolina in 2013. Her thesis focused on the use of functionalized nano-biomaterials to study the bone regeneration process. With her colleagues from graduate school, she joined Integrated Micro-Chromatography Systems (IMCS), a biotechnology incubator company back then, as the second employee. She grew with the company and is currently a Senior R&D and Applications Scientist at IMCS, where she played a pivotal role in the development of IMCSzyme®, the industry’s first genetically modified beta-glucuronidase. She also leads the IMCStips® application development, where she manages tip-based automation solutions for micropurification and preparation of biomolecules.

Moderator: Demi Garvin, B.S., Pharm.D., F-ABFT Expand

Dr. Demi Garvin has over 30 years of experience in the clinical and forensic toxicology fields. She received her Pharm.D. from the University of South Carolina College of Pharmacy (USC) and began her career at the South Carolina Law Enforcement Division Forensic Services Laboratory where she worked as a staff clinical and forensic toxicologist and drug chemist for the next sixteen years. After joining the Richland County Sheriff’s Department (RCSD) in 2000 where she established the agency’s Drug Identification Section, she became Assistant Laboratory Director in 2006 and was subsequently appointed Laboratory Director in 2008. In 2016, Dr. Garvin became Director of Forensic Services for Forensic Science Network, a privately held company that offers forensic testing, training, education, case consultation, and quality management services. She also served as DPX Technologies business development and quality manager from 2016-2018. Dr. Garvin has served as adjunct clinical pharmacy preceptor and adjunct instructor for the USC College of Pharmacy and Department of Chemistry and Biochemistry, respectively. She was an independent contractor in workplace drug testing for the National Laboratory Certification Program at the direction of the Substances and Mental Health Services Administration for twenty-five years. She was a certified South Carolina Law Enforcement Officer for twenty-eight years.

Are urine samples destroying your β-glucuronidase enzyme? Why do some enzymes work beautifully with reference materials and eventually fail when challenged with real human samples? Join us as we walk you through this phenomenon. Learn how you can prevent your difficult urine samples from compromising your confirmatory tests and prevent the likelihood of false negatives.

At the end of this webinar, participants will:

  • Recognize urine-induced differences in hydrolysis efficiency
  • Learn about inhibitors and deactivators that are naturally present in human urine
  • Prevent the likelihood of false negatives by choosing the right enzyme
View Webinar

ACCESS OUR ON-DEMAND SHOWCASE!

And Learn How Enzymes Fail

Customize Your Workflow

IMCS recognizes our customers’ needs vary, which is why we provide tailored tools and services to help you reach your laboratory’s goals.

VIEW OUR CUSTOM SOLUTIONS

ABOUT IMCS

INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC. (IMCS) IS A BIOTECHNOLOGY COMPANY FOCUSED ON DELIVERING TOOLS AND SERVICES THAT HELP PAVE THE WAY FOR THE FUTURE OF PRECISION MEDICINE. WE STRIVE TO ADDRESS THE GROWING NEEDS OF CLINICAL AND RESEARCH LABORATORIES THROUGH ADVANCED TECHNOLOGIES THAT INCREASE TESTING EFFICIENCY AND ACCURACY.

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ABOUT

ABOUT IMCS

CAREERS

QUALITY POLICY

RESEARCH AT IMCS

PRODUCTS

IMCSZYME

IMCSZYME RT

IMCSTIPS

PROTEINS, ENZYMES, RESINS

GLYCO REAGENTS

TERMS

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FCOI POLICY

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IMCS, Inc. Headquarters
110 Centrum Drive
Irmo, SC 29063

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Caleb-Schlachter-for-web

Caleb R. Schlachter, Ph.D.

Principal Scientist
Caleb R. Schlachter, Ph.D., as the Principal Scientist at IMCS, leads and provides guidance for several research and development projects that involve proteins, including enzymes for glycan hydrolysis and glycan synthesis. He has co-authored multiple patents, posters, and peer-reviewed articles on β-glucuronidases and sulfatases.
Gray Amick for web

Gray D. Amick, Ph.D.

Director of Operations
Gray D. Amick, Ph.D., is the Director of Operations at IMCS with over 26 years of experience in forensic DNA analysis and toxicology. Prior to joining IMCS, he led forensic DNA testing for the Richland County Sheriff’s Department as technical leader and lab director. He has been court-qualified as an expert over 100 times and has authored and co-authored multiple posters and peer-reviewed articles.
Amanda M Headshot

Amanda C. McGee

Research Scientist
Amanda C. McGee is a Research Scientist at IMCS involved with enzyme characterizations, new analytical method developments, and advanced technical support. She joined IMCS with several years of experience in analytical testing for active pharmaceutical ingredients as per cGMP, USP and ICH guidelines. She has co-authored peer reviewed articles in the Journal of Analytical Toxicology and presented research at national and international conferences.
Andrew_Headshot

L. Andrew Lee, Ph.D.

Co-Founder and Chief Scientific Officer
L. Andrew Lee, Ph.D. co-founded IMCS and leads research and development efforts in enzyme engineering and automated micro-chromatography workflows. He directs new market efforts in glycan synthesis, supported by three NIH Fast-Track awards.

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