SOFT 2020 ON-DEMAND SHOWCASE SESSION:
How Enzymes Fail: The Hidden Secrets of Urine-Induced Inhibition
Are urine samples destroying your β-glucuronidase enzyme? Why do some enzymes work beautifully with reference materials and eventually fail when challenged with real human samples? Join us as we walk you through this phenomenon. Learn how you can prevent your difficult urine samples from compromising your confirmatory tests and prevent the likelihood of false negatives.
At the end of this webinar, participants will:
- Recognize urine-induced differences in hydrolysis efficiency
- Learn about inhibitors and deactivators that are naturally present in human urine
- Prevent the likelihood of false negatives by choosing the right enzyme



Dr. Ana Grenier has more than 20 years of analytical experience in analytical method development in a variety of industries including the food, pharmaceutical and clinical industries. She received her PhD from the University of Guadalajara (Mexico) where her research focused on developing analytical techniques for monitoring aging makers in Tequila. Since then she has worked in a variety of positions within the pharmaceutical industry in the greater Boston area. In her current position, Dr. Ana Grenier is a Research Scientist in the analytical development group at Dominion Diagnostics where she focuses primarily on utilizing high resolution accurate mass spectrometry for measuring drug levels in human biological fluids.
Dr. Sitasuwan received her Ph.D. in Chemistry and Biochemistry from the University of South Carolina in 2013. Her thesis focused on the use of functionalized nano-biomaterials to study the bone regeneration process. With her colleagues from graduate school, she joined Integrated Micro-Chromatography Systems (IMCS), a biotechnology incubator company back then, as the second employee. She grew with the company and is currently a Senior R&D and Applications Scientist at IMCS, where she played a pivotal role in the development of IMCSzyme®, the industry’s first genetically modified beta-glucuronidase. She also leads the IMCStips® application development, where she manages tip-based automation solutions for micropurification and preparation of biomolecules.
Dr. Demi Garvin has over 30 years of experience in the clinical and forensic toxicology fields. She received her Pharm.D. from the University of South Carolina College of Pharmacy (USC) and began her career at the South Carolina Law Enforcement Division Forensic Services Laboratory where she worked as a staff clinical and forensic toxicologist and drug chemist for the next sixteen years. After joining the Richland County Sheriff’s Department (RCSD) in 2000 where she established the agency’s Drug Identification Section, she became Assistant Laboratory Director in 2006 and was subsequently appointed Laboratory Director in 2008. In 2016, Dr. Garvin became Director of Forensic Services for Forensic Science Network, a privately held company that offers forensic testing, training, education, case consultation, and quality management services. She also served as DPX Technologies business development and quality manager from 2016-2018. Dr. Garvin has served as adjunct clinical pharmacy preceptor and adjunct instructor for the USC College of Pharmacy and Department of Chemistry and Biochemistry, respectively. She was an independent contractor in workplace drug testing for the National Laboratory Certification Program at the direction of the Substances and Mental Health Services Administration for twenty-five years. She was a certified South Carolina Law Enforcement Officer for twenty-eight years.
