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IMCS

IMCS

A leader in recombinant enzymes and automated micro-chromatography technologies

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WEBINARS

ON-DEMAND WEBINAR:

Automating Protein A Purification through Tryptic Digest LC-MS/MS for Studying Post-Translational Modifications on mAbs

Presenter: Stephen D'eri, MS Expand

Steve D'EriStephen D’Eri has spent most of his Biopharma career involved in protein biochemistry. He started in the early 2000s at Wyeth, purifying proteins for structural studies. In 2010, he joined the Structural Protein Chemistry (SPC) group at Genzyme where his main focus was using a variety of analytical techniques to define protein structure-function relationships. He led the group in 2013 to work for Warp Drive Bio where he mainly focused on mass spec proteomics for target identification and high-throughput mass spec screening methods for candidate compounds. He re-joined the SPC group, now known as the Characterization Group for Sanofi in early 2016. He now leads a small automation group where they use robotics and high-level programming languages to support analytical workflows and data analysis.

Presenter: Janna Liptak, MS Expand

Janna Liptak received her bachelor’s degree in Biochemistry and master’s degree in Biotechnology from Northeastern University. She began her professional career at Tetraphase Pharmaceuticals where she worked in the Analytical Chemistry and Formulations group developing HPLC assays for tetracyline-based drug candidates. She transitioned into protein analytics after joining the Sanofi Bioanalytics Characterization group in 2017. In this role she became proficient in a variety of analytical techniques to understand protein structure and function. She utilized automation to streamline laboratory workflows and reduce the burden on analysts in the group. As a member of the newly formed Automation group at Sanofi, she continues to develop analytical methods on robotic systems and implement digital solutions to fulfill the needs of Bioanalytics.

Moderator: Carter Mitchell, PhD Expand

Carter Mitchell is a protein chemist and structural biologist with 20 years of direct experience isolating and characterizing difficult proteins from a variety of recombinant and natural sources. He earned a PhD in Structural Biology where he enzymatically characterized and solved the structures of a multidomain proteins involved in the biosynthesis of metabolites. During his first postdoctoral fellowship he developed and led a drug discovery pipeline with a team of scientists that isolated and characterized bioactive small-molecules and peptides from mammalian microbiomes as well as solved the structure of a unique peptide with novel secondary structural elements. At the National Cancer Institute, Carter focused on the isolation of bioactive proteins from marine aqueous extracts, which required creative purification strategies and earned the Director’s Innovation Award. Prior to joining Kemp Proteins, he was the Chief Technology Officer and Director of Structural Biology at a Biotech start-up where he built, developed, and implemented protein expression and isolation laboratory and managed the protein production and purification team.

Rapid technological growth in analytical instrumentation and data processing has enabled researchers to develop powerful new methods for use in the biopharmaceutical industry. Unfortunately, sample preparation methods have progressed at a much slower rate, leading to a bottleneck in high-throughput analytics. By incorporating automation into our sample preparation and data analysis methods, we address the bottleneck issue while supporting harmonization of workflows across multiple sites.

At the end of this webinar, participants will:

  • Recognize the benefits of automating Protein A purification, buffer exchange, and tryptic digestion workflows
  • Gain an understanding of the dispersive solid phase extraction technology
  • Identify the advantages of automated Protein A purification compared to manual methods
  • Understand the advantages of designing harmonized workflows across multiple sites
View Webinar

ACCESS OUR ON-DEMAND WEBINAR TODAY!

And Learn How Sanofi Addressed Bottlenecks And Harmonized Workflows Across Multiple Global Sites

Customize Your Workflow

IMCS recognizes our customers’ needs vary, which is why we provide tailored tools and services to help you reach your laboratory’s goals.

VIEW OUR CUSTOM SOLUTIONS

ABOUT IMCS

INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC. (IMCS) IS A BIOTECHNOLOGY COMPANY FOCUSED ON DELIVERING TOOLS AND SERVICES THAT HELP PAVE THE WAY FOR THE FUTURE OF PRECISION MEDICINE. WE STRIVE TO ADDRESS THE GROWING NEEDS OF CLINICAL AND RESEARCH LABORATORIES THROUGH ADVANCED TECHNOLOGIES THAT INCREASE TESTING EFFICIENCY AND ACCURACY.

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ABOUT

ABOUT IMCS

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IMCS, Inc. Headquarters
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Irmo, SC 29063

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Caleb-Schlachter-for-web

Caleb R. Schlachter, Ph.D.

Principal Scientist
Caleb R. Schlachter, Ph.D., as the Principal Scientist at IMCS, leads and provides guidance for several research and development projects that involve proteins, including enzymes for glycan hydrolysis and glycan synthesis. He has co-authored multiple patents, posters, and peer-reviewed articles on β-glucuronidases and sulfatases.
Gray Amick for web

Gray D. Amick, Ph.D.

Director of Operations
Gray D. Amick, Ph.D., is the Director of Operations at IMCS with over 26 years of experience in forensic DNA analysis and toxicology. Prior to joining IMCS, he led forensic DNA testing for the Richland County Sheriff’s Department as technical leader and lab director. He has been court-qualified as an expert over 100 times and has authored and co-authored multiple posters and peer-reviewed articles.
Amanda M Headshot

Amanda C. McGee

Research Scientist
Amanda C. McGee is a Research Scientist at IMCS involved with enzyme characterizations, new analytical method developments, and advanced technical support. She joined IMCS with several years of experience in analytical testing for active pharmaceutical ingredients as per cGMP, USP and ICH guidelines. She has co-authored peer reviewed articles in the Journal of Analytical Toxicology and presented research at national and international conferences.
Andrew_Headshot

L. Andrew Lee, Ph.D.

Co-Founder and Chief Scientific Officer
L. Andrew Lee, Ph.D. co-founded IMCS and leads research and development efforts in enzyme engineering and automated micro-chromatography workflows. He directs new market efforts in glycan synthesis, supported by three NIH Fast-Track awards.

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