IMCS
Integrated Micro-Chromatography Systems, Inc (IMCS) is a biotechnology company focused on delivering tools and services to...
IMCS’ CSO Dr. L. Andrew Lee decided to bring his daughter, Lanee, under his wing in the lab this summer and assign her some fun projects on the INTEGRA Biosciences platform! Integra pipetting robots and IMCStips are an award-winning combination, allowing scientists to automate their protein purification process. The best feature is that it is …
Nucleic acid extraction or purification is crucial in various molecular biology experiments. Several methods are available for nucleic acid extraction or purification, including phenol-chloroform extraction, spin column extraction, and magnetic bead purification. Here are some problems and solutions to maximize yield from these methods
Learn how you could save time with in-well hydrolysis of urine at room temperature for drug testing with the help of IMCSzyme® RT and β-Gone™ Plus β-Glucuronidase Removal Plates (Phenomenex). This in-well hydrolysis method allows you to: Save significant time by conducting hydrolysis directly in the well at room temperature, utilizing IMCSzyme® RT alongside β-Gone™ …
PCR cleanup can be done using various techniques, including ethanol precipitation, bead or column-based purification, and enzymatic procedures. In this blog post, we will discuss the advantages and disadvantages of traditional methods and introduce a faster, hands-free alternative: IMCStips for PCR cleanup using dispersive solid-phase extraction (dSPE) technology.
Our latest publication in SLAS Technology highlights IMCS’s successful incorporation of automated buffer exchange into two fully automated workflows: affinity purification and anion exchange. By using pipet-based dispersive solid-phase extraction (dSPE), these workflows are highly adaptable and can address production constraints for biotherapeutics. The inclusion of buffer exchange as a last step in both workflows enables further integration for downstream processing, saving valuable time and increasing efficiency. These findings demonstrate the benefits of incorporating IMCStips into high-throughput protein and plasmid purification, paving the way for a more streamlined and effective biotherapeutics discovery process.
Historically, microscale protein purification has seen methods like batch extraction, spin column, and magnetic beads. Each has unique operational challenges and hardware needs. While high throughput (HTP) systems aim for optimization, they face hurdles like backpressure and purity control. However, a promising addition is the dispersive solid-phase extraction (dSPE), marking a pivotal advancement in protein purification techniques.
