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Miniaturized Sample Preparation with IMCStips dSPE vs. Traditional Methods

Historically, microscale protein purification has seen methods like batch extraction, spin column, and magnetic beads. Each has unique operational challenges and hardware needs. While high throughput (HTP) systems aim for optimization, they face hurdles like backpressure and purity control. However, a promising addition is the dispersive solid-phase extraction (dSPE), marking a pivotal advancement in protein purification techniques.

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Urine Variability Could Compromise Efficiency of β-Glucuronidase Hydrolysis

Urine Hydrolysis Using IMCSzyme® RT INTRODUCTION Are urine samples destroying your β-glucuronidase enzyme? Why do some enzymes work with reference materials and eventually fail when challenged with real human samples? Does the enzyme you choose matter? Learn how you can prevent your difficult urine samples from compromising your confirmatory tests and prevent the likelihood of …

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IMCStips® XT 4Flow HC: Automated Tip-Based Purification of Strep-tagged Proteins

We collaborated with our friends at IBA Lifesciences to bring to you IMCStips® packed with the high-performance Strep-Tactin®XT 4Flow® resin: IMCStips® XT 4Flow HC. This next-generation resin, coupled with IMCStips technology and Hamilton Microlab® STAR automation allows for a pipette tip-based workflow with: High reproducibility and reduced hands-on time without the back-pressure issues found in …

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Simplified Urine Drug Testing with IMCSzyme® RT and β-Gone™ Plus

Learn how you could simplify urine drug testing and sample preparation by combining β-Gone™ Plus β-Glucuronidase Removal and IMCSzyme® RT. We collaborated with Phenomenex to come up with an integrated urine drug testing and sample preparation workflow that will help you: Bypass the need for extra plastic consumables and additional transfer steps that could lead …

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Application Note: Affinity Purification with IMCStips and INTEGRA’s Pipetting Robots

What are the advantages of incorporating Protein A IMCStips® with INTEGRA’s pipetting robots? High reproducibility with error-free pipetting Reduced hands-on time and unmatched ergonomics Dispersive solid phase extraction (dSPE) pipette tips facilitate maximum contact between resin and analyte leading to higher recoveries in less time The results shown in this application note demonstrate the consistent …

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What is Multi-Attribute Method (MAM) and how would it streamline sample preparation?

Multi-attribute method (MAM) is a mass spectrometry-based technique that enables users to simultaneously monitor and quantify molecular attributes with the potential to impact the efficacy, pharmacokinetics, and safety of biotherapeutic applications. From proof-of-concept and product development to real-time quality control, MAM is intended to consolidate separate assays and streamline laboratory workflows. Current sample preparation for …

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