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3 RECENT ADVANCEMENTS IN ANTI-DOPING TESTING FOR ATHLETES

February 25, 2019

Anti-doping technology has never been more advanced. As performance athletics around the world grow in stature and profitability, athletes (and more notably, their trainers) are continuing to look for new ways to circumvent traditional drug testing methods. The stakes have never been higher.

The most recent advancements in athlete drug testing are almost incomprehensible. Here are three ways labs are working to stay ahead of the cheating curve.

Image of a swimmer doing laps in a blue wet cap

1. Retroactive Liquid Testing

The absolute most accurate way to test for banned substances today is to test liquid samples retroactively. By drawing blood and/or urine at the competition site, researchers are able to more accurately – and more comprehensively – test their content offsite using specialized hydrolyzation methods. In fact, dozens of athletes came under fire just last year when their long-dormant samples from the 2008 Beijing Olympics retroactively tested positive for banned substances.

2. Long-term Metabolites

The window during which anabolic steroid metabolites will still be present in an athlete’s sample is lengthening. Thanks to finely-tuned testing methods – often iterations of mass spectrometry – labs are now able to detect residual steroid metabolites for months (rather than just a few weeks) after an event has taken place. These tests are primarily useful for substances like metandienone, oxymetholone, and stanozolol, which are classified as general steroids.

3. Gene Doping Tests

More and more, athletes are being given synthetic DNA that codes for erythropoietin, also known as “EPO,” to up red blood cell count and increase oxygen delivery to the muscles. Since EPO is naturally occurring in the human body, detection of abuse is difficult. Certain techniques, such as scanning blood samples for EPO that is missing critical introns (as synthetic DNA would be), and inspecting for unusual sugar decorations left by bacteria rather than by humans, are helping stop cheaters in their tracks.

IMCS and our team of biological researchers believe in the science of drug testing. Performance enhancing drugs have come a long way over the last century, but the advancements seen over the last decade alone mean scientists have their work cut out for them. In the modern world, staying ahead in anti-doping technology means more than detection…it means prediction.

IMCS products are made to produce fast, accurate results for researchers. IMCStips utilize a patented solid-phase extraction technology to advance the science of proteomics; IMCSzyme, our flagship enzyme product, is a genetically modified pure beta glucuronidase that hydrolyzes multiple drug classes quickly and efficiently.

Ready to learn more? 
Reach out to our team today to find out how IMCS technology can advance your testing process.

Category: BLOG, LATEST NEWS
Previous Post:THE HIDDEN COSTS OF LENGTHY DRUG INCUBATION TIMES
Next Post:HOW BIOTECHNOLOGY IS IMPROVING THE HUMAN BODY

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ABOUT IMCS

INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC. (IMCS) IS A BIOTECHNOLOGY COMPANY FOCUSED ON DELIVERING TOOLS AND SERVICES THAT HELP PAVE THE WAY FOR THE FUTURE OF PRECISION MEDICINE. WE STRIVE TO ADDRESS THE GROWING NEEDS OF CLINICAL AND RESEARCH LABORATORIES THROUGH ADVANCED TECHNOLOGIES THAT INCREASE TESTING EFFICIENCY AND ACCURACY.

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Caleb-Schlachter-for-web

Caleb R. Schlachter, Ph.D.

Principal Scientist
Caleb R. Schlachter, Ph.D., as the Principal Scientist at IMCS, leads and provides guidance for several research and development projects that involve proteins, including enzymes for glycan hydrolysis and glycan synthesis. He has co-authored multiple patents, posters, and peer-reviewed articles on β-glucuronidases and sulfatases.
Gray Amick for web

Gray D. Amick, Ph.D.

Director of Operations
Gray D. Amick, Ph.D., is the Director of Operations at IMCS with over 26 years of experience in forensic DNA analysis and toxicology. Prior to joining IMCS, he led forensic DNA testing for the Richland County Sheriff’s Department as technical leader and lab director. He has been court-qualified as an expert over 100 times and has authored and co-authored multiple posters and peer-reviewed articles.
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Amanda C. McGee

Research Scientist
Amanda C. McGee is a Research Scientist at IMCS involved with enzyme characterizations, new analytical method developments, and advanced technical support. She joined IMCS with several years of experience in analytical testing for active pharmaceutical ingredients as per cGMP, USP and ICH guidelines. She has co-authored peer reviewed articles in the Journal of Analytical Toxicology and presented research at national and international conferences.
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L. Andrew Lee, Ph.D.

Co-Founder and Chief Scientific Officer
L. Andrew Lee, Ph.D. co-founded IMCS and leads research and development efforts in enzyme engineering and automated micro-chromatography workflows. He directs new market efforts in glycan synthesis, supported by three NIH Fast-Track awards.

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