IMCS

Integrated Micro-Chromatography Systems, Inc (IMCS) is a biotechnology company focused on delivering tools and services to...

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IMCSzyme RT Hydrolysis Performance

IMCSzyme RT Stability
Application Notes
Poster Presentations
Poster Summaries
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Journal Articles
Journal Articles
  1. Guterstam J, Tavic C, Barosso M, Beck O. (2024). A multicomponent LC-MS/MS method for drugs of abuse testing using volumetric DBS and a clinical evaluation by comparison with urine. Journal of Pharmaceutical and Biomedical Analysis. doi:10.1016/j.jpba.2024.116075
  2. Li X, Plotkina N, Bryksin J. (2023). Quantitation of Bupropion in Urine by Liquid Chromatography-Tandem Mass Spectrometry. In Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols. New York, NY: Springer US. doi: 10.1007/978-1-0716-3541-4_11
  3. Lessard-Lord J, Auger S, Demers S, Plante PL, Picard P, Desjardins Y. (2023). Automated High-Throughput Quantification of Phenyl-γ-valerolactones and Creatinine in Urine by Laser Diode Thermal Desorption. Journal of Agricultural and Food Chemistry. doi: 10.1021/acs.jafc.3c03888
  4. Rosano TG, Cooper JA, Scholz KL, Wood M. (2023). Confirmation of cannabinoids in forensic toxicology casework by isomer-selective UPLC–MS-MS analysis in urine. Journal of Analytical Toxicology. doi:10.1093/jat/bkad048
  5. Lessard-Lord J, Plante PL, Desjardins Y. (2022). Purified recombinant enzymes efficiently hydrolyze conjugated urinary (poly)phenol metabolites. Food & Function. doi: 10.1039/d2fo02229j
  6. Rydberg M, Dowling S, Manicke NE. (2022). Automated and High-Throughput Urine Drug Screening Using Paper Spray Mass Spectrometry. Journal of Analytical Toxicology. doi: 10.1093/jat/bkac053.
  7. Helmer E, Karimian N, Van Assche K, Seghers I, Le Tallec S, Cherala G, Scott G, Namour FS. (2022). Ziritaxestat Drug–Drug Interaction with Oral Contraceptives: Role of SULT1E1 Inhibition. Clinical Pharmacology & Therapeutics. doi: 10.1002/cpt.2689
  8. Mata DC, Davis JF. (2022). Simultaneous quantitative analysis of 39 common toxicological drugs for increased efficiency in an ante- and postmortem laboratory. Forensic Science International, p.111246. doi: 10.1016/j.forsciint.2022.111246.
  9. Jagerdeo E, Auger S. (2022). Rapid screening procedures for a variety of complex forensic samples using a Laser Diode Thermal Desorption (LDTD) coupled to different mass spectrometers. Forensic Science International, p.111246. doi: 10.1002/rcm.9244.
  10. Reber JD, Karschner EL, Seither JZ, Knittel JL, Walterscheid JP. (2021). Screening and confirmation methods for the qualitative identification of nine phytocannabinoids in urine by LC-MS/MS. Clinical Biochemistry, 98, pp.54-62. doi: 10.1016/j.clinbiochem.2021.09.005.
  11. Feng S, Strickland E, Enders J, Roslawski M, McIntire T, McIntire G. (2021). Ritalinic acid in urine: Impact of age and dose. Practical Laboratory Medicine. doi: 10.1016/j.plabm.2021.e00258.
  12. Okoye NC, Greene DN, Johnson-Davis KL. (2021). Is the Confirmatory Test Always Right? Sometimes Immunoassays Know What They Are Talking About. The Journal of Applied Laboratory Medicine. doi: 10.1093/jalm/jfab097.
  13. Karakükcü Ç, Çıracı MZ, Kocer D, Faydalı MY, Serdar MA. (2021). Evaluation of optimal urine screening and confirmation cut-off values for opiates, at a national reference laboratory. Turkish Journal of Biochemistry. doi: 10.1515/tjb-2020-0614
  14. Lee LA, McGee AC, Sitasuwan P, Tomashek JJ, Riley C, Muñoz-Muñoz AC, Andrade L. (2021). Factors Compromising Glucuronidase Performance in Urine Drug Testing Potentially Resulting in False Negatives. Journal of Analytical Toxicology. doi: 10.1093/jat/bkab090.
  15. Rosano TG, Rumberger JM, Wood M. (2021). Matrix Normalization Techniques for Definitive Urine Drug Testing. Journal of Analytical Toxicology. doi: 10.1093/jat/bkab052.
  16. Zuo LS, Tang XY, Xiong F, Liu YP, Liu M, Ling CW, Sun TY, Ling W, Zhang ZQ, Chen YM. (2021). Isoflavone biomarkers are inversely associated with atherosclerosis progression in adults: a prospective study. The American Journal of Clinical Nutrition. doi: 10.1093/ajcn/nqab008.
  17. Schlachter CR, McGee AC, Sitasuwan PN, Horvath GC, Karri NG, Lee LA, Tomashek JJ. (2021). Variants of Glycosyl Hydrolase Family 2 β-Glucuronidases have Increased Activity on Recalcitrant Substrates. Enzyme and Microbial Technology. doi: 10.1016/j.enzmictec.2020.109742.
  18. Kennedy D, Dani M. (2020). Comparative Analysis of ELISA Immunoassay and LC-QTOF for Opiate Screening. Journal of Analytical Toxicology. doi: 10.1093/jat/bkz109.
  19. Krotulski AJ, Mohr AL, Logan BK. (2020). Emerging synthetic cannabinoids: development and validation of a novel liquid chromatography quadrupole time-of-flight mass spectrometry assay for real-time detection. Journal of Analytical Toxicology. doi: 10.1093/jat/bkz084.
  20. Krotulski AJ, Cannaert A, Stove C, Logan BK. (2020). The next generation of synthetic cannabinoids: Detection, activity, and potential toxicity of pent-4en and but-3en analogues including MDMB-4en-PINACA. Drug Testing and Analysis. doi: 10.1002/dta.2935.
  21. Sofalvi S, Lavins ES, Kaspar CK, Michel HM, Mitchell-Mata CL, Huestis MA, Apollonio LG. (2020). Development and Validation of an LC–MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction. Journal of Analytical Toxicology, bkaa072. doi: 10.1093/jat/bkaa072
  22. Feng S, Ward LF, Parish B, Strickland EC, Enders JR, McIntire G. (2020). Dose Dependent Urine Concentrations of Gabapentin (Neurontin®). Journal of Pharmaceutical Research; 5(1):22-26. doi: 10.33140/jpr.05.01.05
  23. Rosano TG, Ohouo PY, Wood M. (2020). Application of High-Resolution UPLC–MSE/TOF Confirmation in Forensic Urine Drug Screening by UPLC–MS/MS. Journal of Analytical Toxicology; 43(5):353-63. doi: 10.1093/jat/bky106
  24. Muñoz-Muñoz AC, Pekol T, Schubring D, Hyland R, Johnson C, Andrade L. (2020). Characterization of an Amphetamine Interference from Gabapentin in an LC–HRMS Method. Journal of Analytical Toxicology, 44(1), 36-40. doi: 10.1093/jat/bkz046.
  25. Winborn J, Kerrigan S. (2019). Stability and Hydrolysis of Desomorphine-Glucuronide. Journal of Analytical Toxicology. doi: 10.1093/jat/bkz021. [Epub ahead of print]
  26. Kang MG, Lin HR. (2019).  Systematic Evaluation and Validation of Benzodiazepines Confirmation Assay Using LC-MS-MS. Journal of Analytical Toxicology; 43(2):96-103. doi: 10.1093/jat/bky071.
  27. Strickland EC, Cummings OT, McIntire GL, Mellinger AL. (2019). Development and Validation of a Novel All-Inclusive LC–MS-MS Designer Drug Method. Journal of Analytical Toxicology; 43(3):161-9. doi: 10.1093/jat/bky087.
  28. Sitasuwan P, Melendez C, Marinova M, Spruill M, Lee LA. (2019). Comparison of Purified β-glucuronidases in Patient Urine Samples Indicates a Lack of Correlation Between Enzyme Activity and Drugs of Abuse Metabolite Hydrolysis Efficiencies Leading to Potential False Negatives. Journal of Analytical Toxicology. 43(3):221-227. doi: 10.1093/jat/bky082
  29. Feng S, Ward L, Parish B, et al. (2019). Urine drug testing concentration ranges for select benzodiazepines. Journal of Analytical & Pharmaceutical Research; 8(1):8-13. doi: 10.15406/japlr.2019.08.00303
  30. Wang FR, Fei J, Yu XL, Zhao XC, Wang Q, Metavarayuth K. (2018). Advancing the Analysis of Terbutaline in Urine Samples Using Novel Enzyme Hydrolysis. Bioanalysis. doi: 10.4155/bio-2018-0145
  31. Muñoz-Muñoz AC, Pekol T, Schubring D, Johnson C, Andrade L. (2018). Identification of Novel Opioid Interferences using High-Resolution Mass Spectrometry. Journal of Analytical Toxicology; 42(1):6-16. doi: 10.1093/jat/bkx065. Open Access
  32. Cummings OT, Strickland EC, Enders JR, McIntire GL. (2018). Impact of β-Glucuronidase Mediated Hydrolysis on Haldol® Urinalysis. Journal of Analytical Toxicology; 42(4):214-219. doi: 10.1093/jat/bkx103.
  33. Enders JR, Smith JP, Feng S, Strickland EC, McIntire GL. (2018). Analytical considerations when developing an LC-MS/MS method for more than 30 analytes. The Journal of Applied Laboratory Medicine, 2(4), 543-554. doi: 10.1373/jalm.2017.024174
  34. Rasmussen NN, Barker A, Strathmann FG. (2018). Lowering the bar for mass spectrometry: a comparison between immunoassay and rapid time-of-flight for presumptive screening of drugs in urine. The Journal of Applied Laboratory Medicine, 2(4), 535-542. doi: 10.1373/jalm.2017.024166
  35. Feng S, Cummings OT, McIntire G. (2018). Zolpidem and Zolpidem Carboxylic Acid Results from Medication Monitoring. Journal of Analytical Toxicology; 42(7):491-5. doi: 10.1093/jat/bky033.
  36. Dwivedi P, Zhou X, Powell TG, Calafat AM, Ye X. (2018). Impact of enzymatic hydrolysis on the quantification of total urinary concentrations of chemical biomarkers. Chemosphere; 199:256-62. doi: 10.1016/j.chemosphere.2018.01.177.
  37. Johnson-Davis KL. (2018). Opiate & Benzodiazepine Confirmations: To Hydrolyze or Not to Hydrolyze is the Question. Journal of Applied Laboratory Medicine; 2(4):564. doi: 10.1373/jalm.2016.022947. Review Article.
  38. Taylor LL, Flint NA, Ma V, Hill BM, Clark CJ, Strathmann FG. (2017). Internal Hydrolysis Indicator for Sample Specific Monitoring of β-Glucuronidase Activity. Journal of Analytical Toxicology; 41(5):407-411. doi: 10.1093/jat/bkx027.
  39. DiBattista A, Rampersaud D, Lee H, Kim M, Britz-McKibbin P. (2017). High throughput screening method for systematic surveillance of drugs of abuse by multisegment injection–capillary electrophoresis–mass spectrometry. Analytical chemistry;89(21):11853-61.doi: 10.1021/acs.analchem.7b03590
  40. Rosano TG, Ohouo PY, Wood M. (2017). Screening with Quantification for 64 Drugs and Metabolites in Human Urine using UPLC–MS-MS Analysis and a Threshold Accurate Calibration. Journal of Analytical Toxicology; 41(6):536-46. doi: 10.1093/jat/bkx035.
  41. Yang HS, Wu AH, Lynch KL. (2016). Development and Validation of a Novel LC-MS/MS Opioid Confirmation Assay: Evaluation of β-glucuronidase Enzymes and Sample Cleanup Methods. Journal of Analytical Toxicology; 40(5):323-329. doi: 10.1093/jat/bkw026.
  42. Sitasuwan P, Melendez C, Marinova M, Mastrianni K, Darragh A, Ryan E, Lee LA. (2016). Degradation of Opioids and Opiates During Acid Hydrolysis Leads to Reduced Recovery Compared to Enzymatic Hydrolysis. Journal of Analytical Toxicology; 40(8):601-607. doi: 10.1093/jat/bkw085.
  43. Rosano TG, Ohouo PY, LeQue JJ, Freeto SM, Wood M. (2016). Definitive Drug and Metabolite Screening in Urine by UPLC–MS-MS Using a Novel Calibration Technique. Journal of Analytical Toxicology; 40(8):628-38. doi: 10.1093/jat/bkw050.
  44. Mastrianni KR, Lee LA, Brewer WE, Dongari N, Barna M, Morgan SL. (2016). Variations in enzymatic hydrolysis efficiencies for amitriptyline and cyclobenzaprine in urine. Journal of Analytical Toxicology; 40:732-737. doi: 10.1093/jat/bkw062.
  45. Morris AA, Chester SA, Strickland EC, McIntire GL. (2014). Rapid Enzymatic Hydrolysis Using a Novel Recombinant β-Glucuronidase in Benzodiazepine Urinalysis. Journal of Analytical Toxicology; 38(8):610-614. doi: 10.1093/jat/bku083.