LATEST RESOURCES
Review and download IMCStips resources below.
PRODUCT SHEETS
Journal Articles
- Anderson GK, Hicks M, Hamlyn P, Lee LA, Kates PA (2026). Automated optimization of resin selection, wash parameters, and elution parameters for protein A-based purifications. New Biotechnology. 91:17-26. doi:10.1016/j.nbt.2025.11.004.
- Li Q, Hadidi M, Benner S, Ma J (2025). Accelerating AAV purification process development using high-throughput resin tip module. Biotechnol. Prog. 2025:e70053. doi:10.1002/btpr.70053.
- Zilberleyb I, Kugel C, Patel P, Tam C, Hsu PL, Franke Y, Pahuja KB. (2023). End-to-End Semi-automated Mid-scale Protein Screening Platform for Drug Discovery Research. Current Protocols. 3(9), e872. doi:10.1002/cpz1.872.
- Kates PA, Cook JN, Ghan R, Nguyen HJ, Sitasuwan P, Lee LA. (2023). Incorporation of automated buffer exchange empowers high-throughput protein and plasmid purification for downstream uses. SLAS technology. doi: 10.1016/j.slast.2023.01.005.
- Ogata Y, Quizon PM, Nightlinger NS, Sitasuwan P, Snodgrass C, Lee LA, Meyer JD, Rogers RS. (2021). Automated multi-attribute method sample preparation using high-throughput buffer exchange tips. Rapid communications in mass spectrometry. doi: 10.1002/rcm.9222.
- Sitasuwan P, Powers TW, Medwid T, Huang Y, Bare B, Lee LA. (2021). Enhancing the multi-attribute method through an automated and high-throughput sample preparation. mAbs. 13(1):1978131. doi: 10.1080/19420862.2021.1978131.
- Mitchell C, Moore DM, Kates PA, Stevens J, Sly J, Lee LA. (2021). Evaluation of a novel peptide-based affinity ligand for human IgM purification: Use of an automated liquid-handling system for rapid assessment of binding kinetics and capacity. BioProcess International. 19(1-2):46-48.
- Jongkamonwiwat N, Ramirez MA, Edassery S, Wong AC, Yu J, Abbott T, Pak K, Ryan AF, Savas JN. (2020). Noise exposures causing hearing loss generate proteotoxic stress and activate the proteostasis network. Cell reports. 33(8):108431. doi: 10.1016/j.celrep.2020.108431.
- Kates PA, Tomashek JJ, Miles DA, Lee LA. (2020). Parallel sample processing using dispersive INtip micro-purification on programmable multichannel pipettes. BioTechniques. 68(3):148-54. doi: 10.1177/2472555219878152.
- Mullis BT, Hwang S, Lee LA, Iliuk A, Woolsey R, Quilici D, Wang Q. (2020). Automating complex, multistep processes on a single robotic platform to generate reproducible phosphoproteomic data. SLAS DISCOVERY: Advancing the Science of Drug Discovery. 25(3):277-86. doi: 10.1177/2472555219878152.
- Gravel A, Guérette C, Fortin D, Auger S, Picard P, Segura PA. (2019). Further studies on the signal enhancement effect in laser diode thermal desorption-triple quadrupole mass spectrometry using microwell surface coatings. Journal of Mass Spectrometry. 54(12):948-56. doi: 10.1002/jms.4328.
Application Notes
- Comparative IMCStip-Based Protein A Purification on the Tecan Fluent: Impact of Resin and Elution pH on Antibody Aggregation
- High-Throughput Purification and Desalting of His-Tagged Proteins on the Analytik Jena CyBio Felix
- Automated Antibody Purification and Buffer Exchange Using Protein A and SizeX150 IMCStips® on the Opentrons Flex®
- SizeX50 for automated buffer exchange and desalting on the Tecan platform
- Comparison of Different Anion Exchange Resins in IMCStips to Assess Binding Capacities
- Plasmid Purification using 5 mL MidiPure™ IMCStips® on the Dynamic Devices Lynx
- SizeX750 and SizeX1000 IMCStips® for desalting and buffer exchange on the Dynamic Devices platform
- Affinity purification of TST-Proteins using Strep-Tactin®XT 4Flow® High Capacity in IMCStips®
- Semi-automated affinity purification at microgram and milligram scales using IMCStips on INTEGRA’s ASSIST pipetting robot
- Automated Purification of Antibodies from CHO Media Using IMCStips® Containing Protein A Resin
Poster Presentations
- PepTalk 2026: Building Better Purifications: Automation-Enabled Optimization Across Chromatography Workflows
- ACS Spring 2025: Automated optimization of resin selection, wash parameters, and elution parameters for protein A-based purifications
- SLAS 2025: Automated High-Throughput Plasmid DNA Purification with 5 mL IMCStips on Dynamic Devices Lynx Platform
- SLAS 2025: Automating lower throughput repetitive and tedious protein purifications with a variable span pipetting system
- SLAS 2025: Comparative IMCStip-Based Protein A Purification on the Tecan Fluent: Impact of Resin and Elution pH on Antibody Aggregation
- PepTalk 2025: Automated High-Throughput Protein and Plasmid Purification with Integrated Buffer Exchange
- SLAS 2024: An automated plasmid purification protocol – avoiding ancillary equipment and reducing manual intervention
- SLAS 2024: Fully automated size exclusion chromatography workflows for biomolecules with Dynamic Devices Lynx, for sample volumes of 100 µL up to 1 mL
- SLAS 2023: INtip workflow on automated liquid handlers for microgram scale, Low Endotoxin Plasmid Purifications
- SLAS 2023: Automated Two-step High-throughput Protein Purification Incorporating Affinity Chromatography and Buffer Exchange
- ASMS 2022: Automated sample preparations to analyze time treatments of thymidylate inhibitors on colon cancer cell lines
- PEGS 2022: Affinity Purification Followed by Buffer Exchange Using INtip dSPE on an Automated Liquid Handler for High Throughput Protein Purifications
- PEGS 2022: Automated Workflow for Purification and Buffer Exchange of Low-Endotoxin Plasmid DNA
- SLAS 2022: Automated Plasmid Purification Workflow on the Dynamic Devices Lynx
- SLAS 2022: Affinity Purification Followed by Buffer Exchange Using INtip dSPE on an Automated Liquid Handler for High Throughput Protein Purifications
- PepTalk 2022: Automated purification of 5 mL lysates using dispersive solid phase extraction in pipettes
- ASMS 2021: Using phosphoproteomics to understand thymidylate synthase inhibitor treatments of colorectal cancer cell lines
- PepTalk 2021: One-step Automated Protein Purification using dispersive Solid-Phase Extraction (dSPE)
- PEGS 2020: Automated affinity purification and subsequent buffer exchange of recombinant proteins in a single system
- PEGS 2020: Evaluation of Protein A resins for automated workflows utilizing dispersive solid-phase extraction
- ASMS 2020: Use of immobilized trypsin in proteomic workflows enables full automation and reduces undesirable by-products
- ASMS 2020: Automation of Sample Preparation and Buffer Exchange for Multi-Attribute Method
- ASMS 2020: Efficiency of In-tip extractions for peptide desalting and phosphopeptide enrichments using commercially available automated liquid handling systems
- CASSS 2019: Evaluation of Automated MAM Sample Preparation Utilizing SizeX IMCStips®on Hamilton Robotics
- SLAS 2019: Integrating Complex Multi-Method Workflows on a Single Hamilton® Microlab STAR™ Workstation Using INtip™ Chemistries
- SLAS 2019: Modular Automated Sample Extractions using IMCStips® on Hamilton®Microlab STAR™ for High Throughput Protein Purifications
- PEPTALK 2019: Automating Multi-Attribute Monitoring Process for At-Line Monitoring of Biotherapeutics
- PEGS 2019: Increased Throughput of INtip Affinity Purification for Larger Sample Volume
- PEGS 2019: Expanding Functionality of Automated Liquid Handling Systems by Incorporating INtip Chemistries for High Throughput Protein Purification
- ASMS 2019: Using Quantitative Phosphoproteomics to Understand Key Phosphorylation Signaling Pathways in HCT116 Cells After Chemotherapy Drug Treatment
- PEGS 2018: Automated Protein Purification using Hamilton® Microlab STAR™ with Various Wet Resins to Achieve Miniaturized Laboratory Workflow with High Consistencies
- ASMS 2018: Automated Immunoaffinity Enrichment for Phosphotyrosine Peptides Using Protein A and Streptavidin IMCStips®
- ASMS 2017: Comparison of Different Resins for Automated Phosphopeptide Enrichments for Deep-Profiling of HCT116 Cell Line
- ASMS 2017: Automated Peptide Desalting Using Dispersive Pipette Extraction Tips for Increased Protein Identifications
- ASMS 2017: Automated High-throughput Phosphopeptide Enrichment Using TiO2 Dispersive Pipette Extraction
- MSACL 2017: Dispersive Pipette Extraction for Automated Enrichment of IGF-1 from Serum
- SLAS 2017: Affinity-Based Dispersive Pipette Extraction for Automated Purification
Webinars
- Leveraging Automated High-throughput Clonal Selection: How MicroScale Purifications Prevent Bottlenecks and Increase Success
- Automated Multi-Attribute Method (MAM) Sample Preparation
- Automating Protein A Purification through Tryptic Digest LC-MS/MS for Studying Post-Translational Modifications on mAbs
